Teos Ancient City, located near Sığacık in the Seferihisar District of İzmir, dates back to 1000 BCE. Its importance persisted due to the cult of Dionysus, and it was home to the Dionysus Artists' Union in the 3rd century BCE. The city features impressive remains, including the Ionian-style Temple of Dionysus, designed by Hermogenes, and its theatre. The Bouleterion has a semi-circular design with 16 rows of seats, and the city was protected by 3.7 km of Hellenistic fortification walls. Teos, once a major port city, also features well-preserved southern port ruins and a church with double apses.

Kolophon is one of the oldest and most important cities of Ionia. The city, referred to as "lovely Kolophon" by the poet Mimnermos of İzmir in the 7th century BCE, was founded by immigrants from Pylos. Initially an Aeolian city, Kolophon became an Ionian settlement in the 8th century BCE. Famous for its wealth and maritime skills, Kolophon eventually lost its power due to excessive luxury. The city first came under the rule of Lydia and then the Persians. Rebuilt in 281, Kolophon was eventually absorbed into Notion and became known as "New Kolophon." It continued to exist as an independent city during the Roman period.

The city, established on the peninsula known today as Kısık between Gümüldür and Ürkmez, is one of the 12 Ionian cities and was founded in the 7th century BCE. This ancient city, where people forcibly brought from Ephesus were settled, never achieved an active life. However, it was one of the "Polis" that minted coins in the name of the city throughout history. Not much remains of the ancient city; however, the Hellenistic walls in the harbor, the gymnasium, and traces of the temple terrace and residential ruins that have survived to this day on the slope and above the hill behind it can still be seen.

Ephesus, on the western coast of Asia Minor, was an important city in the ancient Mediterranean world and the capital of the Roman province of Asia. Known for its key role in East-West trade, the city developed around the temple of Artemis and later became a center for the spread of Christianity, particularly through the missions of St. Paul. Ephesus flourished during the Roman Imperial period, particularly during the reign of Augustus, with impressive structures including the Prytaneion, hippodrome, aqueducts, the Great Theatre, and the Library of Celsus. One of the largest in the ancient world, the Great Theatre could seat an estimated 25,000 spectators and was used for both dramatic performances and public gatherings. One of the most beautiful buildings in Ephesus, the Library of Celsus, was built in honor of the Roman senator Tiberius Julius Celsus Polemaeanus and housed thousands of scrolls, serving as a monumental tomb for Celsus. Built during Tiberius' reign, the Agora was a bustling commercial center. Recognized for its outstanding universal value, Ephesus has been inscribed on the UNESCO World Heritage List for its cultural and historical significance. While in the area, visitors can explore the nearby village of Şirince, known for its winemaking and preserved architectural charm.

Erythrai, located in the region today known as Ildırı, is 22 kilometers from Çeşme. The name of the city means "red" in Greek. It is said that the region was named so because of the red color of its soil, and according to another theory, it was named by the “red” Erythos, the son of its first founder, Cretan Rhadamanthes. The city, where trade was very intense, was also famous for the millstones that were produced and sold abroad for a period. Excavations in the city have unearthed the Temple of Athena, a theater, a monumental tomb (Heroon), villas from the Hellenistic and Roman periods, and settlement walls.